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Conventional Steroid Treatments for Brain Radionecrosis

Typically, treatment for brain radionecrosis begins when the patient first complains of symptoms. Usually, steroids are given, and if they do not work, the injured part of the brain is removed by surgery.

 

Steroids have been shown to reduce swelling in the brain, but how this happens is not fully understood. Doctors believe that steroids help by reducing the amount of liquid that can be transported into the brain to cause swelling. This helps to restore normal transfer of chemicals between the brain and the blood.

 

For patients who aren't helped by initial steroid therapy, the doses of steroids are increased until the symptoms of brain radionecrosis are stabilized or controlled. This course of treatment is limited because the very high doses of steroids needed by some patients cannot be continued long term without significantly increasing the risk of side effects. Common side effects for long term use of steroids include:

     • internal bleeding
     • glucose intolerance
     • suppression of the immune system
     • weight gain
     • weakness